Polyamines: Methods and Protocols by Anthony E. Pegg (English) Paperback Book

Description: Polyamines by Anthony E. Pegg, Robert A. Casero, Jr. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology. Back Cover Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols , leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular Biology(tm) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology. Table of Contents Current Status of the Polyamine Research Field.- Exploring Polyamine Biosynthetic Diversity through Comparative and Functional Genomics.- Characterization of Genes for Polyamine Modulon.- Posttranscriptional Regulation of Gene Expression in Epithelial Cells by Polyamines.- Identification, Chemical Synthesis, and Biological Functions of Unusual Polyamines Produced by Extreme Thermophiles.- Polyamine Block of Inwardly-Rectifying Potassium Channels.- Carcinogenesis Studies in Mice with Genetically Engineered Alterations in Polyamine Metabolism.- Transgenic Rodents with Altered SSAT Expression as Models of Pancreatitis and Altered Glucose and Lipid Metabolism.- Use of (Gyro) Gy and Spermine Synthase Transgenic Mice to Study Functions of Spermine.- A Simple Assay for Mammalian Spermine Oxidase: A Polyamine Catabolic Enzyme Implicated in Drug Response and Disease.- Characterization, Assay, and Substrate Specificity of Plant Polyamine Oxidases.- Assay of Deoxyhypusine Synthase Activity.- Assay of Deoxyhypusine Hydroxylase Activity.- Identification and Assay of Allosteric Regulators of S-Adenosylmethionine Decarboxylase.- Protocols for Studying Antizyme Expression and Function.- Identification, Assay, and Functional Analysis of the Antizyme Inhibitor Family.- Post-Transcriptional Regulation of Ornithine Decarboxylase.- Identification and Assays of Polyamine Transport Systems in Escherichia coli and Saccharomyces cerevisiae.- Genetic and Biochemical Analysis of Protozoal Polyamine Transporters.- Heparan Sulfate Proteoglycan-Mediated Polyamine Uptake.- Polyamine Transport Systems in Mammalian Cells and Tissues.- Procedures to Evaluate the Importance of Dietary Polyamines.- Determination of N1,N12-Diacetylspermine in Urine: A Novel Tumor Marker.- Spermidine/spermine-N1-Acetyltransferase in Kidney Ischemia Reperfusion Injury.- Use of Polyamine Metabolites as Markers for Stroke and Renal Failure.-Methods to Evaluate Alterations in Polyamine Metabolism Caused by Helicobacter pylori Infection.- High-Resolution Capillary Gas Chromatography in Combination with Mass Spectrometry for Quantification of Three Major Polyamines in Post-Mortem Brain Cortex.- Spermine Synthase Deficiency Resulting in X-Linked Intellectual Disability (Snyder-Robinson Syndrome).- Methylated Polyamines as Research Tools.- Fluorescent Substrates for Polyamine Catabolic Enzymes and Transport.- Use of Polyamine Derivatives as Selective Histone Deacetylase Inhibitors.- Measurement of Polyamine pKa Values.- Polyamine Analysis by LC-MS. Feature -Contains comprehensive and extensive practical coverage of polyamine-related methodologies in a wide variety of subject areas -Features step-by-step protocols, clearly written and readily reproducible -Includes expert tips and key implementation advice to ensure methodological success Details ISBN1493958399 Pages 523 Publisher Humana Press Inc. Series Methods in Molecular Biology Year 2016 ISBN-10 1493958399 ISBN-13 9781493958399 Format Paperback Publication Date 2016-08-23 Imprint Humana Press Inc. Subtitle Methods and Protocols Place of Publication Totowa, NJ Country of Publication United States Edited by Robert A. Casero, Jr. DEWEY 572.548 Short Title Polyamines Language English Series Number 720 UK Release Date 2016-08-23 AU Release Date 2016-08-23 NZ Release Date 2016-08-23 US Release Date 2016-08-23 Author Robert A. Casero, Jr. Edition Description Softcover reprint of the original 1st ed. 2011 Alternative 9781617790331 Audience Professional & Vocational Illustrations XIV, 523 p. We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:126662829;

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